Alopecia

Therapy for Alopecia Areata in Mice by Stimulating the Hair Cycle with Parathyroid Hormone Agonists Linked to a Collagen-Binding Domain. Katikaneni R, Seymour AW, Gulati R, Ponnapakkam T, Gensure R.
J Investig Dermatol Symp Proc. 2015 Nov;17(2):13-5. doi: 10.1038/jidsymp.2015.32.

Parathyroid hormone linked to a collagen binding domain promotes hair growth in a mouse model of chemotherapy-induced alopecia in a dose-dependent manner. Katikaneni R, Ponnapakkam T, Seymour A, Sakon J, Gensure R.
Anticancer Drugs. 2014 Aug;25(7):819-25. doi: 10.1097/CAD.0000000000000110.

Treatment and prevention of chemotherapy-induced alopecia with PTH-CBD, a collagen-targeted parathyroid hormone analog, in a non-depilated mouse model. Katikaneni R, Ponnapakkam T, Matsushita O, Sakon J, Gensure R.
Anticancer Drugs. 2014 Jan;25(1):30-8. doi: 10.1097/CAD.0b013e3283650bff.

Therapy for alopecia areata in mice using parathyroid hormone agonists and antagonists, linked to a collagen-binding domain. Katikaneni R, Gulati R, Suh D, Sakon J, Seymour A, Ponnapakkam T, Gensure R.
J Investig Dermatol Symp Proc. 2013 Dec;16(1):S61-2. doi: 10.1038/jidsymp.2013.25.

Treatment for chemotherapy-induced alopecia in mice using parathyroid hormone agonists and antagonists linked to a collagen binding domain. Katikaneni R, Ponnapakkam T, Suda H, Miyata S, Sakon J, Matsushita O, Gensure RC.
Int J Cancer. 2012 Sep 1;131(5):E813-21. doi: 10.1002/ijc.27379. Epub 2012 Jan 24.

Bone Disorders

Treating osteoporosis by targeting parathyroid hormone to bone. Ponnapakkam T, Katikaneni R, Sakon J, Stratford R, Gensure RC.
Drug Discov Today. 2013 Aug 6. pii: S1359-6446(13)00253-5. doi: 10.1016/j.drudis.2013.07.015. [Epub ahead of print]

A single injection of the anabolic bone agent, parathyroid hormone-collagen binding domain (PTH-CBD), results in sustained increases in bone mineral density for up to 12 months in normal female mice. Ponnapakkam T, Katikaneni R, Suda H, Miyata S, Matsushita O, Sakon J, Gensure RC.
Calcif Tissue Int. 2012 Sep;91(3):196-203. doi:10.1007/s00223-012-9626-1. Epub 2012 Jul 18.

Prevention of chemotherapy-induced osteoporosis by cyclophosphamide with a long-acting form of parathyroid hormone. Ponnapakkam T, Katikaneni R, Nichols T, Tobin G, Sakon J, Matsushita O, Gensure RC.
J Endocrinol Invest. 2011 Dec;34(11):e392-7. doi: 10.3275/7864. Epub 2011 Jul 12.

Monthly administration of a novel PTH-collagen binding domain fusion protein is anabolic in mice. Ponnapakkam T, Katikaneni R, Miller E, Ponnapakkam A, Hirofumi S, Miyata S, Suva LJ, Sakon J, Matsushita O, Gensure RC.
Calcif Tissue Int. 2011 Jun;88(6):511-20. doi: 10.1007/s00223-011-9485-1. Epub 2011 Apr 22.

Pharmacokinetics

Pharmacokinetics in Rats of a Long-Acting Human Parathyroid Hormone-Collagen Binding Domain Peptide Construct. Stratford R Jr, Vu C, Sakon J, Katikaneni R, Gensure R, Ponnapakkam T.
J Pharm Sci. 2014 Jan 7. doi: 10.1002/jps.23843.